Hi everyone, for those of you looking for accurate Tysabri information...,

These are various reports/data which were released awhile ago at the AAN regarding the outcomes of Tysabri meeting and exceeding primary endpoints and the newest data released 61st annual AAN meeting which shows that Tysabri promotes remyelination, woo hoo!

As to efficacy in preventing further relapses, the percentages of the different ABCR drugs versus Tysabri (67%-29%) were as follows:

Tysabri was 67%, Avonex (Interferon beta-1a IM) 32%, Betaseron(R) (Interferon beta-1b) 34%, Copaxone(R) (glatiramer acetate) 29%, and Rebif(R) (Interferon beta-1a SC) 32%.

Data Show Tysabri Had Improvement in Quality of Life Assessments

Tysabri Impacts Measures of Visual Function

Tysabri Impacts Measures of Disability Progression

Data Demonstrates Tysabri Significantly Reduced Corticosteroid Use, Hospitalizations and Increases the Proportion of Disease-Free Patients

Tysabri Has Sustained Effect on Relapse Rate in Multiple Sclerosis Patients Treated for up to Three Years

Tysabri Significantly Reduces Vision Loss Tysabri

Demonstrates Significant Improvement in Cognitive Function in Patients with Multiple Sclerosis

Tysabri Demonstrates Significant Improvement in Functional Outcomes

Tysabri Is the Only Marketed MS Treatment To Show Both Significant Slowing In Disability Progression and Sustained Improvement in Physical Disability

***28 April 2009** MRI Data Showing Tysabri Promoted Remyelination Presented at the 61st Annual Meeting of the American Academy of Neurology -- Additional data suggests improvement in Tysabri patients across clinical and patient-reported outcomes

http://www.elan.com/News/full.asp?ID=840112

http://www.elan.com/News/full.asp?ID=913012

http://www.elan.com/News/full.asp?ID=910437

*** http://www.elan.com/News/full.asp?ID=913012 ***

http://www.medpagetoday.com/Ophthalmology/GeneralOphthalmology/tb/5453

*** http://www.elan.com/News/full.asp?ID=910099 ***

*** http://www.elan.com/news/full.asp?ID=1199030 ***

*** http://www.elan.com/News/full.asp?ID=1281713 ***

Hope this information helps those of you looking for accurate Tysabri information..., enjoy the rest of your week everyone, I know I will!

((((hugs))))
Love, Lauren

My Tysabri Diary...

Hi everyone, I completed my 33rd Tysabri infusion last Wednesday (wow, have I had that many already?). Everything went fine and I even found out that my neurologist started another patient on Tysabri, woo hoo!

With respect to the latest PML case reported, I am not concerned at all... in fact, I would like to share with all of you the following (these remarks are from a treating neurologist that prescribes Tysabri and is an acquaintance of mine):

"Tysabri

The Benefits

1. Reported reduction in relapse rates 100% better than any exisitng therapy. Comparable MRI results.

2. Reported reduction in disability of progression up to 50% better than any existing therapy. Since this is a LAGGING indicator, expect the reduction in disability progression to get better and better (COMPOUNDING) assuming yearly reduction in relapse rates holds.

3. First drug to show quality of life improvements

4. First drug to show IMPROVEMENT in visual function

5. First drug to show reduction in fatigue

6. First drug to show significant subset of patients demonstrating IMPROVEMENT in EDSS scores.

7. First drug to demonstrate significant HAULT in ALL evidence of disease activity for a significant subset of patient population.

8. First drug to demonstrate significant improvement in patients with highly active MS

9. First drug to show significant improvement in Cognitive function (to be presented at an upcoming MS conference

10. First drug to show in-vivo evidence of re-myelination


The Risks -

1. Increase risk of liver enzyme elevations......... in very rare patient - jaundice

2. Increase risk of opportunisitc infections - small increase risk of herpetic reactivation

3. PML - 6 confirmed cases since re-introduction out of over 55,000 patient exposures, 40,000 active patients, and probably upwards of 40,000 patient years of drug. Well within label.

One death - I have been told that this one patient death was from IRIS and that patient and/or family refused hospitalization and treatment (to be hopefully confirmed at AAN)

PML serious potential side effect, with often moderate to severe neurological sequella. Importantly, NOT a death sentence, and can be detected early through clinical vigilence. MAY be treatable through PLEX and methoquine.

As to the most current MS patient that developed PML, this is from a German blog, and also a German friend of mine stated "the docs out there were amongst the first to leave the DDR via Hungary - before the wall fell.

With docs and nurses gone west - add techers too - the DDR was about to lose so many qualified people , which the state depended on, that this fact was one of the major reasons they finally had to open the border. Many of the docs who escaped the DDR have moved back since.

What I have seen from patients' posts - was that TY had been prescribed for patients who would normally not qualify as RRMS .... many of them claiming you just had to go to certain ms-centers --- in Leipzig or Dresden, know what to say and you would get your TY.

The following has been translated from a German blog:

formerly East-Germany.

15.04.2009	?	31 Monate	?	?	6
Anmerkung: weitere Informationen folgen. Spekulation: Ist Deutschland nicht das einzige Land, außer den USA, indem Tys vor 31 Monaten schon zugelassen war? Gerüchteweise Dresden Tini Am 23. April 2009 um 15:50 Uhr Hallo, ich war heut bei meinem Neurologen. Er hat mir gesagt, dass der 6. PML-Fall in Dresden ist. Ich hoffe Pit, deiner Frau geht es besser. Ich wünsche dir viel Kraft und ihr alles alles Gute. Tini says that she had been to her neurologist today and he told her that the 6th case was from Dresden

She also stated: "But, I would say that there are also Neuros in western Germany, who treat their patients with mainly Aza and Mitox, due to low costs ( imo )

I know that for maybe 10 years now, docs in general have to prescribe generica - if they are exactly the same compounds as the original med-

Many patients write that they will take Ty "nevertheless" ( pml fear ) because " what else is there left for us to go on ?"

I hope BIIB sees what they are doing with their 1st Avonex policy :they degraded Ty to an escalation therapy, which means to some neuros, try everything else first and then TY.

It only takes a few of these uninformed specialists ...who think they are informed, but never take the time to read the newest abstracts."

Take care everyone,

((((hugs))))
Love, Lauren

My Tysabri Diary..

Happy Easter everyone!

Whether or not you are a believer in Easter, I wanted to share a beautiful story of the white Easter Lily, a funny photo of two chocolate Easter bunnies (I think I've shared this before but I still find it a very funny photo), and a hysterical "Bunny Rap" which should put a smile on your face - LOL

My Easter prayer this morning is that each of you be blessed beyond belief with good health, a loving family/friends to share your life with, financial prosperity, and a happy heart...,

Easter blessings one and all!

Lauren

On Easter Day the lilies bloom,
Triumphant, risen from their tomb;
Their bulbs have undergone rebirth,
Born from the silence of the earth
Symbolically, to tell all men
That Christ, the Savior, lives again.
The angels, pure and white as they,
Have come and rolled the stone away
And with the lifting of the stone,
The shadow of the cross is gone!

June Masters Bacher

Here's the hysterical "Bunny Rap"..., enjoy! Bunny Rap